Decreasing the dosage or stopping the medication will mitigate symptoms within hours. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Compulsive fiddling with your mask? But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. The differences are obvious to untrained eyes. While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. We should not wait for the Phase 3 RCT. See more below. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. P-value was 10^-14 on that study (done by Dr. Seftel). It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. So the drug had no chance of working (since there were no events), so the trial was stopped for futility, NOT because the drug doesnt work. Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." The track management was so impressed, they asked for prescriptions. Still, in the moment, his question threw me, and I stuttered. My website www.skirsch.io has tons of info on fluvoxamine with all the links. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. This site requires JavaScript to run correctly. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. The NIH wrote a bullshit rejection because the FDA told them not to approve it. (Clayton Fox, Marty Makary, and Jeffrey Klausner). and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora My experience is very typical. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Hes now outlived his initial prognosis by several years. There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. The race to find covid-19 drug treatments that actually work, The antimalarial drug Trump took for covid might actually be dangerous. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. Kirsch said that his attempts to promote fluvoxamine are being curtailed. If you start 5 days after symptoms, all bets are off. . upcoming events, and more. This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. Timing is everything with respect to outcomes. Doctors who have used fluvoxamine in the US and other countries swear by it. But they dont want their names used. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Read More fluvoxamine The Fluvoxamine FAQ This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. The evidence is solid. Kirsch did a lot of things right when he set up CETF. He has made millions from these projects, even if they have not turned him into a household name. You can help by bringing this document to your doctor's attention. Steve Kirsch is baffled. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. . But the potential upsides. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Who knows, Morris replied. Personal life. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Fluvoxamine has at least a 30% hospitalization and death benefit. I believe they made the right decision and we should be rushing to follow their advice. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. Hilary Grant-Valdez Operations Manager Tom Brunner What happens when your prescription drug becomes the center of covid misinformation. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Always be self aware when using fluvoxamine. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. And FrameMaker is still a niche product. But I know something else that few other people know, thanks to a source at the NIH: the NIH was planning to approve fluvoxamine months ago, but they got a call from the FDA telling them not to. Steve put in $1MM of his own money and . Here's why. I see it all the time on social media, Morris told me. 47).. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. Online Status. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. Lack of action. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). Fluvoxamine has a 40 year safety track record. If you continue to get this message, Note that a total of 77 people got the drug, not 65. All have had a 100% success record in keeping their patients out of the hospital. Its the gold standard of medical evidence. Or just depression about the vaccine mandates? Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. He's founded 7 companies, 2 with billion dollar valuations. . Design thinking was supposed to fix the world. They never make things worse so are safe to try. How can we get fluvoxamine? This is what the Seftel trial at Golden Gate fields used. So you can address your OCD and if you get COVID, youll can up the dose. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. (The ivermectin data are trash, Feinberg told me. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. Their willingness to lie did. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. He has been a medical philanthropist for more than 20 years. Try refreshing this page and updating them one Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . Steve angrily decried this development as more evidence of FDA corruption. Medium revoked my account for life. It will be months before enrollments are complete. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Enter the email address you signed up with and we'll email you a reset link. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. He may not be a good scientist, but hes smart, says WVUs Feinberg. The reason is pure corruption. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. . The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. I was just getting tired, he said, before asking to speak off the record. Keeping this drug off the NIH Guidelines does nothing to reduce the death rate. That study was featured on 60 Minutes. Adverse reactions/side effects. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. I couldn't agree more. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. With cases spiking, the Los Angeles area banned gatherings. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. Every year, we pick the 10 technologies that matter the most right now. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. saying that the per-protocol analysis was arbitrary and other excuses. But Kirsch is also motivated by an unsatisfied competitive streak. It has shown to be 100% protective of hospitalization in 2 clinical trials. just like ivermectin). It was approved by the FDA in 1994 and has been used in millions of patients worldwide. To date, we have heard nothing suggesting the drug doesn't work or could be harmful. All can merit a fluvoxamine prescription based on traditional diagnoses. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. One is to reduce the threat of nuclear war. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). The 5 observational studies is icing on the cake. See this Wall Street Journal op-ed. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Most recent articles first. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. The web price charge of skirsch.io . I wanted to get the article out before my flight left. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. The medical community doesnt care about saving lives. Is that really true? [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. Steve Kirsch. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. Some people report mild nausea while on the drug (stops when stop the drug). The results would, eventually, set Kirsch on a collision course with the scientific establishment. Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. So much for evidence-based medicine. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. . The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. Fluvoxamine at 50mg twice a day for 14 days is a very well-tolerated drug (as long as you avoid caffeine and alcohol) for the treatment of COVID infections. Please. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. But fear of trying something new prevents any doctor from giving this drug a try. Completely avoid caffeine, alcohol, tylenol, and benadryl. He has a history of giving away some of his millions to good causes, and when COVID-19 began. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. Steve Kirsch is looking for an explanation for 171,000 excess deaths. 19 In addition, several . Be warned!. Avoid caffeine, benadryl, tylenol, and alcohol. Have the drug on hand. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. Doctors have no excuse for not prescribing. Its whether Merck can make a killing that matters. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. Doctors who are most familiar with the drug would prescribe it to their patients. It doesnt get much better than that. Early treatment with existing drugs is the fastest, most effective, and lowest. The medical community did nothing (with a few exceptions like Dr. Seftel). While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Completely avoid caffeine, alcohol, tylenol, and benadryl. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. Theyre finding alternative leaders to follow, Morris said. has tons of info on fluvoxamine with all the links. . The study was also featured on 60 Minutes. Items included in the Television News search service. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. skirsch.io Steve Kirsch Home page. Those days are gone. If you cant lay off the java, then try fluoxetine (Prozac). The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). If you cant get a prescription for COVID, then perhaps you have OCD? 33. Long haul. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. This advice is now outdated. Hes very convincing. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. My experience is very typical. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Its not about the science. Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. That is when the phase 2 results were published. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. It works best when it is given early, as soon as symptoms start. Quick Summary . ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. . . This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Do they sell it anywhere? Dosing. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). Dosage there is 30mg once a day. We look for advances that will have a big impact on our lives and break down why they matter. It used to be that a Phase 3 study would do it. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. My crime? We could have saved a lot of lives. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. Or just depression about the vaccine mandates? In severe cases, it takes longer. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. And that is what has allowed Kirsch, and people like him, to become so influential.